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G protein-gated inwardly rectifying potassium (GIRK) channels hyperpolarize neurons in response to activation of many different G protein-coupled receptors and thus control the...

Four G protein gated inwardly-rectifying potassium (GIRK) channel subunits have been identified in mammals: GIRK1, GIRK2, GIRK3, and GIRK4. The GIRK subunits come togetgirkher to form GIRK ion channels.

G protein-coupled inwardly rectifying potassium (GIRK) channels can be activated or inhibited by different classes of receptors, suggesting a role for G proteins in determining signaling specificity.

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girk|Activation and inhibition of G protein

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girk|Activation and inhibition of G protein

girk|Activation and inhibition of G protein

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Structural insights into GIRK2 channel modulation by cholesterol。 Structural insights into GIRK2 channel modulation by cholesterol。 Structural insights into GIRK2 channel modulation by cholesterol。 Structural insights into GIRK2 channel modulation by cholesterol。 Structural insights into GIRK2 channel modulation by cholesterol。
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